The objective of the present study was to evaluate the effect of eclipta alba l. It is a nontoxic hepatoprotective substance from the himalaya drug co. In all test model systems conditions for liver damage are implemented and an attempt is made to counteract this toxicosis. Exploring the determinants of repurchase behavior in c2b ecommerce. All the parts of eclipta alba and chemical constituents are used as antileprotic, analgesic, antioxidant, antimyotoxic, antihaemorrhagic, antihepatotoxic, antiviral, antibacterial, spasmogenic. Eclipta alba extract eae was prepared by suspending dry. Review article ethnopharmacological significance of. Evaluating the reversal potentials of hydroalcoholic. Activity may be due to the presence of hematinic factors in eclipta alba.
Evaluation of anti inflammatory activity of eclipta alba in rats. Tabassum n, agrawal ss 2004 hepatoprotective activity of eclipta alba hassk. Extracts of eclipta alba were found to be most active against test bacteria, such as s. Hassk has been widely used in india for the traditional treatment of liver disorders chopra et al. The results indicate the potent antiinflammatory effect and therapeutic efficacy of eclipta alba extract on animal models, which is compared with indomethacin.
Alba protected guinea pigs against mortality from carbon tetrachlorideinduced liver damage. The eclipta alba has been extensively studied for its hepatoprotective activity and a number of herbal preparations comprising of eclipta alba are available for treatment of jaundice and other ailments of the liver and gall bladder and viral hepatitis orning et al. Hepatoprotective activity can be most easily evaluated screened with the aid of several model systems of liver damage in experimental animals. From the whole plant of eclipta alba, a new triterpene saponin, named eclalbatin, together with alphaamyrin, ursolic acid and oleanolic acid were isolated. Antibreast tumor activity of eclipta extract invitro and. Hepatoprotective activity of eclipta alba is well described in literature 33, 3538. Industrial technology development organization, tokyo institute of technology, tokyo, japan.
Traditional medicinal systems of the indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract disorders including asthma, fever, hair loss. Hepatoprotective and cardiac inhibitory activities of. Screening of leaves and roots of eclipta alba for hepatoprotective activity v. The loss of hepatic lysomal acid phosphatase and alkaline phosphatase by ccl 4 was significantly restored by eclipta alba. An ethnomedicinal herb plant, traditionally use in ayurveda. Tikta, kashaya laghu, ruksha ushna katu kaphavatahara. Eightyone wistar albino rats were divided into four groups. Eclipta alba is an important medicinal plant in the traditional system of medicine. This study reported its qualitative and quantitative analyses based on lcms method. Liver cell injury is generally caused by various toxic chemicals certain antibiotic, chemotherapeutic agents, carbon tetrachloride ccl 4.
Abstract eclipta alba is a herb commonly found throughout india. Nyctaginaceae, commonly known as punarnava is a perennial creeping herb widely studied. Eclipta prostrata is a perennial herb, distributed in the tropical and sub tropical regions of the world. The eclipta prostrata extracts significantly inhibited the acute elevation of serum transaminases induced by carbon tetrachloride in mice and by d. Hepatoprotective activity of some indigenous plants. Invivo heptoprotective activity of active fraction from. Multiple telecouplings and their complex interrelationships. Ethnopharmacological significance of eclipta alba l. Comapartive study on hepatoprotective activity of phyllanthus amarus and eclipta prostrata against alcohol induced in albino rats arun. Particle concentration may be expressed in volumetric or gravimetric terms. Biherbal ethanolic extract bhee from the leaves of eclipta alba and seeds of piper longum at a dose level of 50 mgkg body weight was.
Charaka advises taking the juice of eclipta alba with honey to prevent the onset of senility, and its oil as the best medicated massage oils for rejuvenation therapies. Accentuating the prodigious significance of eclipta 1260 pak. An ayurvedic drug from eclipta alba has been found to be quite beneficial for the treatment of jaundice in children dixit and achar,1981. Qualitative and quantitative phytochemical analysis of eclipta alba collected from different geographical locations using spectrophotometry, tlchptlc and rphplc.
Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. Hepatoprotective activity there have been an extensive studies carried out to substantiate the hepatoprotective activity of eclipta alba. Eclipta alba also known as bhringraj is small branched annual plant with a long history of ayurvedic medicinal use for rejuvenation and longevity. Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats j ananthi et al yale journal of biology and medicine 76 2003, pp. Jun 14, 2014 eclipta alba ayurvedic herb caraka indicated it for raktapitta while vagbhata advocated its consumption for one month to have the rasayana effect. Extensive research corroborates the hepatoprotective activity of eclipta alba. The study shows that hepatoprotective activity ofeclipta alba is by regulating the levels of.
These herbal drugs have equivalent therapeutic value with the standards drug silymarin. I n s t i t u t u m b o t a n i c u m f a c u l t a t i s r e r u m n a t u r a l i u m benatska 2, 128 01 prague 2, czech republic novitates. The inhibitory effects of extracts are very similar to those of standard antibiotics used. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of. Qualitative and quantitative phytochemical analysis of. Aqueous extract showed good activity against test spp. Osmotic and activity coefficient studies on the aqueous. Journal of innovations in pharmaceuticals and biological sciences. The in vitro antifungal activity of eclipta alba whole plant extracts has been investigated against candida tropicalis, rhodotorula glutinis and candida albicans. The plant has been reported to exhibit hepatoprotective action on. The protective layer of zebrafish embryo changes continuously with advancing age of embryo development aged. The acute toxicity studies have shown that like ea, fraction eaii also high safety margin.
Eclipta alba at a dose of 50 mgkg was studied in ccl 4, paracetamol, and aflatoxininduced hepatic injury, and has shown hepatoprotective activity by reducing the serum ast, and alt. The study was designed to explore its antiproliferative activity on liver and other related cancer. Thus, ea imparted antioxidant activity by elevating the levels of endogenous antioxidants vitamin e and vitamin c. Hepatoprotective effects of eclipta alba on subcellular.
National chengchi university, 64 zhinan road, section 2, wenshan district, taipei 11605, taiwan. Prepared for delivery at the 2007 meeting of the latin american studies association, montreal, canada, september 58, 2007. Sugar preferences of avian nectarivores are correlated with intestinal sucrase activity kathryn r. Qualitative and quantitative analysis of eclipta prostrata l. Hassk is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical. Eclipta prostrata ep illustration 1a juice has been showed to inhibit cancer and endothelial cell migration in vitro and to have antiangiogenic activity in vivo5. Mode of antibacterial activity of eclalbasaponin isolated from eclipta alba. These studies have given several leads to the antimicrobial, diuretic, hypotensive, and hypocholesterolemic activity, antioxidant, anticancer potential, cerebralprotective.
The study shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes21. Eclipta alba asteraceae is traditional medicinal plant known as bhringaraj. A study conducted by murugaian p et al in 2008, on the whole plant extract of eclipta alba hassk. Hepatoprotective role of eclipta alba against high fatty diet. There are no exclusive markets for the sale of arecanut in kerala. Osmotic and activity coefficient studies on the aqueous solutions of tetramethylurea at 298. Pharmacological activity and chemical constituents of. Eclipta alba is a herb commonly found throughout india. Eclipta alba bhringaraja having important role in the traditional ayurvedic and unani systems of holistic health and herbal medicine of the east. Lal 1, amit kumar 1, prashant kumar 2, kuldeep singh yadav 3 1 department of pharmacy, sagar inst. Effects of eclipta prostrata and eclipta alba on survival. Comparative study on hepatoprotective activity of aegle marmelos and eclipta alba against alcohol induced in albino rats. Exposure to organophosphate pesticides, such as diazinon, can inhibit che activity and it is frequently assumed that decreased activity of che is a biomarker of exposure to these organophosphates. Antibreast tumor activity of eclipta extract invitro and invivo.
Experimental evaluation of the analgesic property of eclipta alba l hassk. Wagner h, geyer b, kiso y, hikino h, rao gs 1986 coumestans as the main active principles of the liver drugs eclipta alba and wedella calendulaceae. Karunakaran arecanut is an important commercial crop in kerala. The present study was undertaken to study the hepato protective. Serum transaminases were also significantly lower in the treated group. The previous studies shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes saxena ak, et al. Alcoholic extract of the plant is known to show protective effect on experimental liver damage in rats and mice 20.
Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice c. A rapid densitometric method for quantification of. Ea significantly counteracted ccl 4induced inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine ndemethylase and membrane bound glucose 6phosphatase, but failed to reverse the very high degree of. The present study investigates the anticancer and multidrug resistance mdr reversal potential of hydroalcoholic eclipta alba extract eae. It is bounded by budhi khola in the east, hardiya khola in the west, charkose jungle in the north and khanar and ekamba v. Vedic guard, a polyherbal formulation is a synergistic combination of 16 medicinal plant extracts contains eclipta alba as a major ingredient46. Extracts of eclipta alba were found to be most active against test bacteria, such. The presence of chemicals in the aquatic environment have had a significant impact on fish health 24,25,37,38. Hepatoprotective role of eclipta alba against high fatty. Dasyscyphin c was isolated from eclipta prostrate which were studied on the hela cells for the anticancer activity 12. The concentration of particles may also vary widely. The effect of various additive excipient was also studied to alter the floating behaviour and drug release from the floating tablet. International journal of environmental sciences volume 2 no. The objectives of this study were to i determine the potential use of near infrared reflectance spectroscopy nirs for amino and fatty acid analysis in soybean seed and ii compare nirs amino and fatty acid equations developed with groundseed and wholeseed soybean samples.
Eclalbatin, a triterpene saponin from eclipta alba. The present paper describes the phytochemical and pharmacological investigations of eclipta alba. Hepatoprotective activities of triphala and its constituents. Hepatoprotective activity of boerhavia diffusa extract. In the chronic model cotton pellet induced granuloma the ceea and standard drug showed decreased formation of granuloma tissue by 49. Pharmacological activity reports hepatoprotective activity. Eclipta alba is traditionally used as hepatoprotective agent. Hepatoprotective activity of boerhavia diffusa extract patel monali, verma ramtej department of zoology, university school of sciences, gujarat university, ahmedabad 380009, india. U 376 international journal of environmental sciences volume 2 no1, 2011 in a test tube containing about 5 ml of plant extract, a drop of sodium bicarbonate was added. Evaluation of hydroalcoholic extract of eclipta alba for its.
Review accentuating the prodigious significance of eclipta. The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Paraskara grhyasutra, kesava paddhati, soundkiya atharva, kousika sathra etc delineate bhrngaraja for its cosmetic as well as medicinal value. Chienhsiang chou1, yuyin wang2, yishun wang3, tzungi tang4. Read hepatoprotective activity of taiwan folk medicine. Screening of antibacterial and antioxidant activities of leaves of eclipta prostrata l.
Antianaphylactic activity of alcoholic extract of eclipta alba. Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats. An alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. Eclipta alba root extract is considered a powerful liver tonic. Grdds, floating tablet, eclipta alba, hepatoprotective. Antiinflammatory constituents from eclipta prostrata using raw264.
Gst may also be increased, especially in diets with low vitamin e, as it is thought to form gsh conjugates with peroxy radicals miller et al. Acetone, ethanol and methanol extracts showed better activity on test bacterial spp. The extracts of eclipta alba showed high degree of activity against all test fungi. Components are the individual components to be combined, which can be sources of evidence, retrieval methods, or both i. Journal of innovations in pharmaceuticals and biological.
Ashish singh 1, sasikumar menon 1 and sunita shailajan2 presenting author 1institute for advanced training and research in interdisciplinary sciences, 194, scheme. Positive and negative experiences from patients with numbness that take vitamin b6. This plant has been well reported to exhibit hepatoprotective activity 2 and in the treatment of infective hepatitis 3. Evaluation of anti inflammatory activity of eclipta alba in.
Comparative study on hepatoprotective activity of aegle. The loss of hepatic lysosomal acid phosphatase and alkaline phosphatase by ccl4 was significantly restored by eclipta alba. Agronomy journal abstract analysis of amino and fatty acid. The plant contains an alkaloid, ecliptine, which has a choleretic action and lipid peroxidation.
Eclipta alba extract while neutrophils were also reduced in hepatotoxic control. Reviews by patients who have numbness and take vitamin b6 either as part of daily diet or as method of treatment. The hepatoprotective activity was monitored by estimating the serum transaminases sgot and sgpt levels and histopathological changes in the liver of experimental animals. Haematological protective effect of raw extract and nano. The plant is an active ingredient of many herbal formulation prescribed for liver ailments and shows effect on liver cell generation 1. The structure of eclalbatin has been established as 3obetadglucopyranosyl3betahydroxyolean12en28oic acid, 28obetadarabinopyranoside 1 on the basis of chemical and spectral. Formulation and estimation of floating tablets of eclipta. Study reports on the development and characterization of e. However, quality control of this herbal medicine has been not satisfactory. It possesses a wide range of biological activities and is used for the treatment of hepatitis and cirrhosis wagner h, 1986 22. It is believed to prevent aging and rejuvenate hair, teeth, bone, memory, sight, hearing. Effects of dietary polyunsaturated fatty acidvitamin e pufa. Eclipta alba can be found growing wild in fallow lands of bangladesh where it is considered as a weed by farmers.
Sugar preferences of avian nectarivores are correlated with. Dec 16, 2012 the physicochemical, catalytic, and antiproliferative activity of a recombinant lasparaginase from yersinia pseudotuberculosis ypa have been studied. Hepatoprotective activity of six polyherbal formulations. The experimental protocol was performed as per cpcsea guide lines. Among the two plants aegle marmelos has slightly high activity as compare to eclipta alba. Chemical composition, pharmacological activities of eclipta alba. Antihyperglycemic activity of eclipta alba leaf on. The phytochemical investigation was carried out to determine the possible bioactive components from the methanol extract of eclipta prostrata leaves by gas chromatography and mass spectroscopy gcms.
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